Computation-based virtual screening for designing novel antimalarial drugs by targeting falcipain-III: A structure-based drug designing approach

Background & objectives: Cysteine proteases (falcipains), a papain-family of enzymes of Plasmodium falciparum, are responsible for haemoglobin degradation and thus necessary for its survival during asexual life cycle phase inside the human red blood cells while remaining non-functional for the human body.Therefore, these can act as potential target

read more

Paradoxical thinning of the retinal nerve fiber layer after reversal of cupping: A case report of primary infantile glaucoma

The circumpapillary retinal nerve fiber layer (RNFL) thickness was fsu headband assessed by spectral domain optical coherent tomography (SD-OCT) before and after surgical reduction of intraocular pressure in an eye with primary infantile glaucoma.In this case, a postoperative reduction of cupping and a subsequent increase in neuroretinal rim area i

read more

The Differential Antagonistic Ability of Curcumin against Cytotoxicity and Genotoxicity Induced by Distinct Heavy Metals

Widespread heavy metal pollution has jumbo wind gold aroused severe health risks worldwide.Curcumin has been reported to play a wide-spectrum protective role for various heavy metals.However, the specificity and difference in the antagonistic ability of curcumin against distinct types of heavy metals are still largely unknown.Here, using cadmium (C

read more

PREOPERATIVE MANAGEMENT OF MAXILLOFACIAL WAR INJURIES.

The complex anatomical structures of the Cervico-Facial area, makes the knowledge of the anatomical extent of the tissue damaged by war injury, and the location of the foreign body or shell, quite difficult.The terms perforating, penetrating and avulsive wounds used in war injuries are merely superficial description; they hide the nature and the ac

read more